Space Exploration Sustainability Act

Space Exploration Sustainability Act - Amends the National Aeronautics and Space Administration Authorization Act of 2010 to make it: (1) a long-term goal for the National Aeronautics Space Administration (NASA) to sustainably expand permanent human presence beyond low-Earth orbit and to expand economic activity in space, and (2) a key objective of the United States to expand throughout cis-lunar space (the region of space from the Earth out to and including the region around the surface of the Moon) and beyond.

Requires the Administrator of NASA to submit to Congress a strategy for achieving the long-term goal of sustainably expanding a human presence beyond low-Earth orbit through robust use of cis-lunar space.

Instructs NASA to proceed with the utilization of the International Space Station, technology development, and follow-on transportation systems, including the space launch system and the multi-purpose crew vehicle.