San Francisco Bay Improvement Act of 2010

San Francisco Bay Improvement Act of 2010 - Amends the Federal Water Pollution Control Act (commonly known as the Clean Water Act) to direct the Administrator of the Environmental Protection Agency (EPA) to: (1) establish a San Francisco Bay Program Office, to be located at EPA's region nine headquarters; and (2) appoint a Director of the Office.

Requires the Administrator, acting through the Director, to: (1) assist and support the implementation of the comprehensive conservation and management plan for the San Francisco Bay; (2) provide funding and make grants for implementation of the comprehensive plan and related projects; (3) promote methodologies and technologies that are cost-effective and consistent with the goals and objectives of the comprehensive plan and the EPA permitting processes; (4) coordinate the major functions of the federal government relating to the implementation of the comprehensive plan; (5) coordinate the research and planning projects authorized under this Act with the San Francisco Estuary Partnership, federal agencies, state agencies, local governments, federally recognized Indian tribes, universities, and other public or nonprofit private organizations; (6) track progress with respect to meeting the identified goals and objectives of the comprehensive plan; and (7) collect and make available to the public publications and information relating to the environmental quality of the San Francisco Bay.

Requires the Administrator to establish a San Francisco Bay Program Advisory Committee to provide advice on the implementation of the comprehensive plan's goals and objectives.

Requires the Administrator, in consultation with the Director of the Partnership, to a report, biennially, to Congress on implementation of the comprehensive plan.

Requires the Administrator, acting through the Director and in consultation with the Partnership, to make grants for projects, programs, and studies to implement the comprehensive plan. Authorizes the Director to make: (1) a comprehensive grant to the Partnership to manage such implementation; and (2) grants to state and regional water pollution control agencies and entities for projects, programs, and studies that advance implementation of the comprehensive plan.

Requires the President, as part of the annual budget, to submit information regarding expenditures and roles of each federal agency involved in San Francisco Bay protection and restoration.