To designate Pennsylvania State Route 60 and United States Routes 22 and 30 as part of the Dwight D. Eisenhower National System of Interstate and Defense Highways, and for other purposes.

Designates a certain segment of Pennsylvania State Route 60 and a segment of U.S. Routes 22 and 30 as part of the Dwight D. Eisenhower National System of Interstate and Defense Highways as Interstate Route 376.

Redesignates Interstate Route 279 from Interstate Route 79 east to Interstate Route 376 at Point State Park, Pennsylvania, as Interstate Route 376/279.