Medicare Clinical Laboratory Fee Schedule Improvement Act of 2006

Medicare Clinical Laboratory Fee Schedule Improvement Act of 2006 - Amends title XVIII (Medicare) of the Social Security Act with respect to: (1) correction of erroneous determinations and other changes in fee schedule and national limitation amounts for clinical diagnostic laboratory tests; (2) issuance of regulations on gap-filling methodology in determining the Medicare fee schedule for such tests; (3) increased transparency of process for determining fee schedule amounts for new tests; and (4) mandatory advance notice of clinical diagnostic laboratory test amounts being considered for adjustment under inherent reasonableness authority.

Directs the Secretary to: (1) establish a demonstration project to evaluate new approaches to coding and payment under the Medicare program for clinical diagnostic laboratory tests; and (2) appoint a standing panel to determine tests to be included in the project and make recommendations derived from project results to the Secretary of Health and Human Services.