To amend the Safe and Drug-Free Schools and Communities Act of 1994 to provide comprehensive technical assistance and implement prevention programs that meet a high scientific standard of program effectiveness.

Amends the Safe and Drug-Free Schools and Communities Act of 1994 (which is part A of title IV of the Elementary and Secondary Education Act of 1965) to establish a new subpart 2, Effective Prevention Program Implementation, providing comprehensive prevention technical assistance grants. Authorizes appropriations.

Authorizes the Secretary of Education to provide such grants to States that meet specified requirements to implement prevention programs that meet a high scientific standard of program effectiveness. Sets forth program requirements for State plans, reservations and allocations of funds, State distribution of program funds through competitive grants to local educational agencies (LEAs), and LEA plans and use of funds for comprehensive prevention programs that meet certain requirements.