To amend section 274 of the Immigration and Nationality Act to impose mandatory minimum sentences, and increase certain sentences, for bringing in and harboring certain aliens and to amend title 18, United States Code, to provide enhanced penalties for persons committing such offenses while armed.

(Sec. 1) Directs the Attorney General to increase by 50 for each of FY 2001 through 2005 the number of Immigration and Naturalization Service (full-time) personnel assigned to investigate and combat alien smuggling.

(Sec. 2) Directs the United States Sentencing Commission to promulgate revised sentencing guidelines for alien smuggling-related activities so as to: (1) double specified minimum prison terms for smuggling, transporting, harboring, or inducement; (2) increase minimum fines; and (3) increase by at least two offense levels sentencing for intentionally or recklessly creating a substantial risk of serious bodily injury or causing bodily injury or death. Exempts from such provisions offenses: (1) committed other than for profit; or (2) involving a defendant's spouse, child, or both.

(Sec. 3) Amends the Immigration and Nationality Act (Act) to exempt from specified alien smuggling or harboring criminal penalties persons rendering life threatening emergency assistance to an alien in the United States.

(Sec. 4) Directs the Commission to revise Federal sentencing guidelines to provide that plea bargaining and other prosecutorial policies, and district policy differences, are not a ground for sentence imposition outside applicable guidelines.

(Sec. 5) Amends Federal criminal law to subject specified alien smuggling and harboring crimes under the Act committed by an armed person to enhanced penalties.

(Sec. 6) Authorizes Service appropriations for alien smuggling-related undercover and enforcement activities.

(Sec. 7) Defines alien smuggling for certain purposes of this Act.